TABLE 7.
The effect of 6BN on pup birthweight.
| 6BN dose (mg/kg) | MTD dose (mg/kg) | Number of pups (n) | Number of litters | Birthweight (g) |
|---|---|---|---|---|
| 0 | 5,7 | 49 (41 at 5 MTD; 8 at 7 MTD) | 9 | 74.9 ± 1.6 |
| 0.025 | 5 | 21 | 5 | 85.8 ± 4.8 |
| 0.075 | 5,7 | 30 (22 at 5 MTD; 8 at 7 MTD) | 8 | 84.2 ± 2.6 |
| 0.3 | 5,7 | 26 (17 at 5 MTD; 9 at 7 MTD) | 6 | 89.8 ± 3.6 a |
| 0.3 | 0 | 11 | 2 | 88.5 ± 3.0b |
| 0 (saline ctl) | 0 | 28 | 6 | 75.6 ± 3.1 |
F(4,149) = 5.484, p = 0.00038 for overall effect of 6BN compared to saline controls, by ANOVA.
a
p < 0.01 compared to saline ctl, by Dunnetts posthoc test; bp < 0.01 compared to saline ctl, by t-test.