Skip to main content
. Author manuscript; available in PMC: 2021 Oct 15.
Published in final edited form as: Pharm Res. 2020 Oct 15;37(11):221. doi: 10.1007/s11095-020-02941-6

Fig. 1. Adipose tissue exosome contents and targets.

Fig. 1

(a) Various cells of adipose tissue have been demonstrated to secrete exosomes containing miRNA, mRNA, lncRNA, circRNA, proteins, lipids, and DNA with active biological function. (b) Reported targets of adipose tissue exosomes, which have been shown to regulate processes such as endothelial cell vascularization (via HIF-1α, Akt, ERK, and SDF-1), myocyte insulin resistance (through PPARG expression), macrophage inflammatory profile (through regulating gene expression and cell metabolism), etc. Furthermore, evidence suggests that systemic regulation by exosomes is common due to their ability to remain functional in vivo after traveling significant distances from donor cells. Created with BioRender.com.