Table 3.
Comparisons between groups with high and low expression of HIF-1α.
| HIF-1α High Expression |
HIF-1α Low Expression |
Odds Ratio | P | |
|---|---|---|---|---|
| (n = 14) | (n = 8) | |||
| Age, y | 62.3 ± 10.8 | 62.3 ± 14.2 | 1 (.93–1.08) | .99 |
| Sex, male | 14 | 7 | > .99 | |
| Polysomnography | ||||
| AHI | 46.5 ± 21.8 | 22.7 ± 22.7 | 1.05 (1.0–1.11) | .04* |
| ODI | 32.8 ± 21.6 | 21.4 ± 21.8 | 1.03 (.98–1.08) | .28 |
| Lowest SpO2 | 82.3 ± 5.6 | 82.7 ± 5.4 | 0.99 (.83–1.17) | .88 |
| Tsat90% | 14.3 ± 26.2 | 16.4 ± 27.1 | 1.0 (.96–1.03) | .86 |
| Cancer stage (%) | ||||
| Stage I | 5 (35) | 1 (12) | > .99 | |
| Stage II | 0 (0) | 1 (12) | ||
| Stage III | 3 (21) | 1 (12) | 0.60 (.03–13.5) | .75 |
| Stage IV | 6 (43) | 5 (63) | 0.24 (.02–2.79) | .25 |
| Pathology (%) | ||||
| Adenocarcinoma | 8 (57) | 5 (63) | > .99 | |
| Squamous cell | 4 (29) | 2 (25) | 1.25 (.16–9.54) | .83 |
| Other | 2 (14) | 1 (12) | 1.25 (.09–17.6) | .87 |
Data presented as mean ± SD or number (percentage). HIF = hypoxia-inducible factor, ODI = oxygen desaturation index, SpO2 = oxygen saturation, Tsat90% = percentage of sleep time with oxygen saturation < 90%.