Figure 3.

Hazard ratio (HR) for the composite outcome MACE by change in low-density lipoprotein cholesterol (LDL-C,mmol/L) from index event to cardiac rehabilitation visit, adjusted for clinical characteristics, and established cardiovascular risk factors. Solid line: hazard ratio with 95% confidence interval (CI), shadowed area, in relation to low-density lipoprotein cholesterol change using restricted cubic splines with four knots. Vertical dotted lines: percentiles. X-axis presented on a linear scale. Population distribution in relation to change in low-density lipoprotein cholesterol below spline. MACE, major adverse cardiovascular event is the composite outcome of cardiovascular mortality, myocardial infarction, and ischaemic stroke.