Table 2.

Biochemical substances for eradicating biofilm

Factors	Target microorganisms	Mechanisms	References
Phage lysins
LysGH15	Staphylococcus	Cleaves Staphylococcus peptidoglycan	(Zhang et al. 2018)
CF-301	S. aureus	Cleaves S. aureus peptidoglycan	(Schuch et al. 2017)
LysH5	S. aureus	Cleaves S. aureus peptidoglycan	(Gutierrez et al. 2014)
P128	Staphylococcus	Cleaves Staphylococcus peptidoglycan	(Poonacha et al. 2017)
Degradative enzymes
Mannosidase, Glucanase	C. auris	Degrades C. auris mannan and glucan in EPS	(Dominguez et al. 2019)
Alginate lyases	P. aeruginosa	Degrades exopolysaccharide alginate	(Jang et al. 2016)
DNase	B. licheniformis, B. subtilis, E. coli, Micrococcus luteus	Degrades eDNA	(Nijland et al. 2010)
DNase	Gardnerella vaginalis	Degrades eDNA	(Hymes et al. 2013)
Metabolites
Carolacton	Sorangium cellulosum	Causes S. mutans biofilm cells death, cell chains elongation, and cell morphology changes	(Kunze et al. 2010)
Rhamnolipid	S. aureus, S. enteritidis, L. monocytogenes	Possesses anti-biofilm and antimicrobial activities	(E Silva et al. 2017; Khalid et al. 2019)
D-amino acids	E. coli	Contribute to the cell-cell repulsion	(Kolodkin-Gal et al. 2010; Xing et al. 2015)