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. 2021 Mar 8;15:997–1011. doi: 10.2147/DDDT.S288369

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© 2021 Ubieta et al.

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Inhibition of Lck phosphorylation by nintedanib. Automated capillary electrophoresis Western blot was performed using antibodies against Lck-Y394 (A) and total Lck (B). Cells were pretreated for 20 min with nintedanib and stimulated for 15 min with αCD3/αCD28. The area under the curve of the intensity of the chemiluminescence signal is shown as mean ± standard deviation of 3 donors. Panel (C) shows example Western blot with Lck-Y394 and cofilin. Panel (D) shows total Lck control Western blot.

Abbreviation: Lck, lymphocyte-specific protein tyrosine kinase.