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. 2021 Mar 8;15:997–1011. doi: 10.2147/DDDT.S288369

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© 2021 Ubieta et al.

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Nintedanib decreases T-cell clustering. (A) Images were taken using an IncuCyte ZOOM live imager of highly purified T cells from healthy donors after 48 hours of activation with αCD3/αCD28, αIL-4, αIFN-γ and IL-2 and pretreated with or without nintedanib at 10, 30 and 100 nM. Scale bar (0–200 µm). (B) The number of clusters per square millimeter is shown for n=5–18 time-lapse videos over 48 hours of n=4–6 donors. Data presented as mean ± standard error of mean, *P<0.05.

Abbreviations: IFN-γ, interferon gamma; IL, interleukin.