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. 2021 Mar 12;16(3):e0248394. doi: 10.1371/journal.pone.0248394

Table 1. Morphometric parameters in the respiratory mechanics of asthmatic and non-asthmatic Swiss mice after treatment with the nitric oxide metallo-donor FOR811A.

Experimental groups Normal Alveoli (%) Alveolar Collapse (%) Mean Alveolar Diameter (μm) Bronchoconstriction index (BCI)
Ctl+Sal 90.03±2.36 9.97±2.36 44.56±3.31 2.05±0.21
Ast+Sal 71.58±6.22* 28.42±6.22* 35.54±5.56* 1.99±0.17
Ctl+FOR 94.25±2.26 5.75±2.26 46.11±7.12 2.84±0.39
Ast+FOR 83.31±4.98 16.69±4.98 41.20±5.88 2.33±0.23

Values are mean ± SD of the following groups: control treated with saline solution (Ctl+Sal), asthmatic treated with saline solution (Ast+Sal), control treated with FOR811A (Ctl+FOR) and asthmatic treated with FOR811A (Ast+FOR). Data was collected in 10 matched fields per mouse. Values significantly different (p<0.05) by one-way ANOVA followed by Student–Newman–Keuls test compared to the Ctl+Sal group (*), and no difference compared to Ctl+Sal group.