Table 1. Morphometric parameters in the respiratory mechanics of asthmatic and non-asthmatic Swiss mice after treatment with the nitric oxide metallo-donor FOR811A.
Experimental groups | Normal Alveoli (%) | Alveolar Collapse (%) | Mean Alveolar Diameter (μm) | Bronchoconstriction index (BCI) |
---|---|---|---|---|
Ctl+Sal | 90.03±2.36 | 9.97±2.36 | 44.56±3.31 | 2.05±0.21 |
Ast+Sal | 71.58±6.22* | 28.42±6.22* | 35.54±5.56* | 1.99±0.17 |
Ctl+FOR | 94.25±2.26 | 5.75±2.26 | 46.11±7.12 | 2.84±0.39 |
Ast+FOR | 83.31±4.98 | 16.69±4.98 | 41.20±5.88 | 2.33±0.23 |
Values are mean ± SD of the following groups: control treated with saline solution (Ctl+Sal), asthmatic treated with saline solution (Ast+Sal), control treated with FOR811A (Ctl+FOR) and asthmatic treated with FOR811A (Ast+FOR). Data was collected in 10 matched fields per mouse. Values significantly different (p<0.05) by one-way ANOVA followed by Student–Newman–Keuls test compared to the Ctl+Sal group (*), and no difference compared to Ctl+Sal group.