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. 2021 Mar 2;17(3):e1009345. doi: 10.1371/journal.ppat.1009345

Fig 6. The tviA 5’ UTR fourU RNA thermosensor is required for S. Typhi evasion of innate immune signaling in human intestinal epithelial cells.

Fig 6

A and B) TLR-dependent signaling as measured by IL-8 secretion from the human intestinal epithelial cell line HT-29 following infection for 6 (A) or 18 (B) hours with non-invasive WT, ΔfliC, ΔtviA, tviA-REP, tviA-REP ΔfliC, or tviA-DEREP S. Typhi at MOI = 25 or left uninfected. Data shown are representative of 2 (B) or 3 (A) independent experiments with triplicate samples for each condition. Data are represented as mean ± SD. Significance calculated using one-way ANOVA with Tukey’s correction. ** p < 0.01, *** p < 0.001, **** p < 0.0001.