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. 2021 Mar 12;16(3):e0240074. doi: 10.1371/journal.pone.0240074

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© 2021 Zapukhliak et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (A) Simultaneous recording of synchronous epileptiform activity induced in synaptic blockers aCSF: (1) bursts of discharges, (2) single epileptiform discharges, (3) epileptiform discharges appear simultaneously in CA3 and CA1, while population spikes only in CA1. (B) Nonsynaptic population spikes appear in low-Ca²⁺ aCSF: (4) epileptiform activity is not synchronized between CA3-CA1 hippocampal zones.