Fig 2. CA3-CA1 synchronization of epileptiform discharges induced in aCSF with AMPA, NMDA, GABA antagonists depends on synaptic connections.

(A) Blockade of the synchronous epileptiform discharges following 15 μM CdCl₂ application: (1) burst of epileptiform discharges and (2) single epileptiform discharges become less synchronized (3) following 15 μM CdCl₂ application and nonsynaptic population spikes (4) appear in CA1. (B) Simultaneous extracellular (upper trace) and intracellular (bottom trace) recording in CA1 during perfusion with synaptic blockers aCSF reveals synaptic currents appear during epileptiform discharges.