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. 2021 Mar 12;16(3):e0240074. doi: 10.1371/journal.pone.0240074

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© 2021 Zapukhliak et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) Effect of nonselective nicotinic antagonist mecamylamine on CA3-CA1 synchronous epileptiform discharges induced in synaptic blockers aCSF: (1) single epileptiform discharges; (2) decrease in epileptiform discharges following 50 μM MEC application; (3) epileptiform discharges after mecamylamine wash out. (B) Simultaneous extracellular (up) and patch clamp recording (bottom) in synaptic blockers aCSF: (4) neuron voltage clamped at -70 mV, (5) neuron voltage clamped at zero mV.