Table 1. Effect of cholinergic antagonists on CA3-CA1 synchronization of epileptiform discharges.
Cholinergic antagonist | Cross-correlation control | Cross-correlation application | Statistical significance (Wilcoxon signed ranks test) | Number of slices | |
---|---|---|---|---|---|
atropine, 10 μM | 0.56 ± 0.15 | 0.38 ± 0.19 | - | p = 0.059 | n = 6 |
d-tubocurarine, 50 μM | 0.55 ± 0.25 | 0.13 ± 0.05 | * | p = 0.036 | n = 6 |
MLA, 100 nM | 0.56 ± 0.08 | 0.31 ± 0.18 | - | p = 0.059 | n = 5 |
DhβE, 10 μM | 0.48 ± 0.22 | 0.43 ± 0.33 | - | p = 0.850 | n = 4 |
MEC, 50 μM | 0.45 ± 0.18 | 0.10 ± 0.09 | ** | p = 0.002 | n = 12 |