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. 2020 Dec 10;144(1):53–69. doi: 10.1093/brain/awaa382

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Flow cytometry of PDGF-driven mouse tumours. (A) Survival curves for Ntva;Cdkn2a^wt^/^wt mice with tumours induced by RCAS-PDGFA or RCAS-PDGFB with co-administration of RCAS-shP53. Log-rank Mantel-Cox test, P < 0.0001. (B) Representative flow cytometry dot plots of PDGFA (n = 7) and PDGFB-driven (n = 9) tumours generated in Ntva;Cdkn2a^wt^/^wt mice, gated for CD45, CD11b, Ly6C, and Ly6G. (C) %CD45^hiCD11b⁻ lymphocytes in the total tumour cell population. (D) %CD45⁺CD11b⁺ myeloid cells in the total tumour cell population, P = 0.0008. (E) %CD45^hiCD11b⁺ BMDMs in the total myeloid cell population, P = 0.0171. (F) %CD45^l°CD11b⁺ microglia in the total myeloid cell population. (G) %CD45^hiCD11b⁺Ly6C^hiLy6G^lo inflammatory monocytes in the total BMDM population, P = 0.0030. (H) %CD45^hiCD11b⁺Ly6C^hiLy6G^hi neutrophils in the total BMDM population. Student’s t-test. ns = not significant.