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. 2021 Mar 12;7(11):eabf1948. doi: 10.1126/sciadv.abf1948

Fig. 5. GIP activity in the α cell is required for glycemic control following a mixed nutrient stimulus.

Fig. 5

(A) Intraperitoneal (ip) glucose tolerance (n = 10, 14; control, Giprα cell−/−), (B) oral glucose tolerance (n = 11, 14; control, Giprα cell−/−), and (C) mixed nutrient glucose tolerance (n = 9, 12; control, Giprα cell−/−) in control or Giprα cell−/− mice. (D) Incremental AUCs (iAUC) are shown for each test. (E) Plasma insulin and (F) plasma glucagon at 0 and 10 min after stimuli in control mice. (G) Plasma insulin and (H) glucagon at 0 and 10 min after stimuli in Giprα cell−/− mice. *P < 0.05; data are shown as means ± SEM.