Fig. 6. Schematic overview of the beneficial metabolic effects of lowering apoCIII in vivo under HFD conditions.

Targeting apoCIII protects against HFD-induced metabolic derangements by increasing lipolysis (1), hepatic clearance of circulating lipids (2), liver lipid catabolism (3), and shifting liver metabolism toward ketogenesis (4). The ketones are taken up (5 and 6) and used for energy production in BAT (7 to 9). LP-Rs, lipoprotein receptors; ECF, extracellular fluid.