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. 2021 Mar 12;7(11):eaba1187. doi: 10.1126/sciadv.aba1187

Fig. 5. TAK-418 ameliorates impaired sociability in VPA rats and poly I:C mice.

Fig. 5

(A and B) Effects of 2-week TAK-418 administration on social impairment in 5-week-old (A) and 15-week-old (B) VPA rats. N = 14 or 15. (C to E) Effects of 2-week TAK-418 administration at 0.1 (C), 0.3 (D), and 1 mg/kg (E) in 22-week-old poly I:C mice. N = 13 or 14. (F) Effects of 2-week TAK-418 administration in VPA rats assessed after 1-week drug withdrawal. N = 14 or 15. (G) Effects of 1-week TAK-418 administration in 5-week-old VPA rats. N = 6 or 10. (H) Effects of single TAK-418 administration in 5-week-old VPA rats. N = 14 or 15. All quantitative data are presented as means + SEM. Student’s t test versus control group, *P < 0.05, **P < 0.01, and ***P < 0.005. Aspin-Welch test versus control group, #P < 0.05 and ###P < 0.005. One-tailed Shirley-Williams test versus vehicle-treated model group, $P < 0.025. One-tailed Williams test versus vehicle-treated model group, ¶¶¶P < 0.005. Student’s t test versus vehicle-treated model group, §P < 0.05, §§P < 0.01, and §§§P < 0.005. Aspin-Welch test versus vehicle-treated model group, †P < 0.05 and †††P < 0.005. ns, no significant difference by each statistical test.