Figure 6. BAFF and APRIL Signals Through BCMA to Have Proinflammatory Functions in Myeloid Cells.

CD11b⁺ myeloid cells were MACS sorted from healthy (A) BCMA^+/+ and (B) BCMA^−/− mice and stimulated with lipopolysaccharides in the presence or absence of BAFF or APRIL (n = 3/group). After 72 hours, supernatants were collected, and IL-6 and IL-10 secretion was measured by ELISA. Error bars represent SEM, and Student t tests were used to determine statistical significance. p < 0.05 was considered to be statistically significant. APRIL = a proliferation-inducing ligand; BAFF = B cell activating factor; BCMA = B cell maturation antigen; EAE = experimental autoimmune encephalomyelitis; IL = interleukin.