Table 2.
Multivariable analysis assessing factors associated with RFS and PFS
| Variable |
Recurrence-free survival (RFS) |
Progression-free survival (PFS) |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age | 0.99 | 0.98–1.01 | 0.668 | 0.99 | 0.97–1.02 | 0.579 |
| Gender (female vs male) | 1.20 | 0.79–1.81 | 0.377 | 1.13 | 0.58–2.21 | 0.709 |
| Smoking (never/any) | 1.13 | 0.81–1.57 | 0.475 | 1.03 | 0.61–1.73 | 0.916 |
| MP in primary TURB (yes/no) | 0.91 | 0.61–1.32 | 0.586 | 0.83 | 0.47–1.45 | 0.497 |
| Concomitant CIS (yes vs no) | 1.58 | 0.94–2.29 | 0.081 | 1.73 | 0.87–3.55 | 0.072 |
| Size (≤3 cm vs >3 cm) | 1.02 | 0.75–1.39 | 0.941 | 1.25 | 0.76–2.07 | 0.375 |
| Focality (solitary vs multiple) | 1.11 | 0.81–1.51 | 0.516 | 1.25 | 0.75–2.09 | 0.384 |
| BCG strain: HR (95% CI); p-value | vs. Moreau | vs. TICE | vs. RIVM | vs. Moreau | vs. TICE | vs. RIVM |
| Moreau | X | 1.03 (0.68–1.58); p = 0.881 | 0.62 (0.40–0.95); p = 0.029a | X | 1.34 (0.72–2.56); p = 0.357 | 0.81 (0.42–1.56); p = 0.523 |
| TICE | 0.97 (0.63–1.47); p = 0.881 | X | 0.60 (0.42–0.87); p < 0.001a | 0.74 (0.39–1.39); p = 0.357 | X | 0.60 (0.34–1.06); p = 0.081 |
| RIVM | 1.61 (1.05–2.47); p = 0.029a | 1.66 (1.15–2.38); p < 0.001a | X | 1.23 (0.64–2.35); p = 0.523 | 1.65 (0.94–2.91); p = 0.081 | X |
a Statistically significant P value. HR >1 worse outcome for the bolded option, HR <1 better outcome for the bolded option.