. Author manuscript; available in PMC: 2021 Mar 12.

Published in final edited form as: Cancer Chemother Pharmacol. 2020 Oct 23;86(6):815–827. doi: 10.1007/s00280-020-04176-z

Table 3.

Mean pharmacokinetic parameters for onalespib and AT7519

					Mean pharmacokinetic parameters for AT7519.^a
Dose level		Dose		C_max	t_1/2,z	AUC	CL	V_z	Dose		C_max	t_1/2,z	AUC	CL	V_z
	Day	(mg/m²)	n	(ng/mL)	(h)	(ng•h/mL)	(L/h/m²)	(L/m²)	(mg/m²)	n	(ng/mL)	(h)	(ng•h/mL)	(L/h/m²)	(L/m²)
1	C0D1	40	5	193	10.0	780	51.3	742
				(25.4)	(9.0)	(17.1)	(17.1)	(18.9)
2	C0D1	80	17	349	10.4	1486	53.8	804
				(56.5)	(41.2)	(29.0)	(29.0)	(28.2)
3	C0D1	80	5	487	9.0	1677	47.7	617
				(35.5)	(24.6)	(3.3)	(3.3)	(25.6)
	C0D1	All	27		10.0		52.2	754
					(34.1)		(24.1)	(27.5)
1	C1D1	40	4	146	9.6	621	64.4	891	21	4	462.8	7.48	1545	13.6	146.6
				(81.1)	(16.0)	(24.2)	(24.2)	(20.5)			(27.8)	(23.0)	(29.7)	(29.7)	(14.4)
2	C1D1	80	16	331	8.7	1392	57.5	721	21	15	459.3	11.1	2300	9.13	146.3
				(40.3)	(31.9)	(26.3)	(26.3)	(26.1)			(22.4)	(33.8)	(43.4)	(43.4)	(23.7)
3	C1D1	80	4	331	7.4	1410	56.7	606	27	4	602.0	9.21	2662	10.1	134.7
				(26.3)	(56.8)	(11.2)	(11.2)	(54.5)	27	4	(25.2)	(18.2)	(12.0)	(12.0)	(27.4)
	C1D1	All	24		8.6		58.4	725	All	23		10.0		9.97	144.3
					(33.9)		(23.7)	(31.6)	All	23		(33.2)		(39.6)	(22.3)
1	C1D11	40	2	155	9.4	610	65.6	855
				(10.4)	(3.5)	(3.2)	(3.2)	(5.4)	21	2	485.7	10.8	2105	9.98	155.9
2	C1D11	80	11	355	8.2	1280	62.5	743
				(57.2)	(16.7)	(35.8)	(35.8)	(39.6)	21	11	508.7	10.7	2449	8.58	132.6
3	C1D11	80	3	424	6.7	1507	53.1	516
				(31.9)	(49.6)	(12.4)	(12.4)	(36.6)	27	2	581.1	9.38	2695	10.0	135.5
	C1D11	All	16		8.1		61.0	706
					(24.3)		(30.3)	(38.8)	All	15		10.5		8.93	135.9