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Mechanisms of the anticancer activity of tangeretin. Cdk2, cyclin-dependent kinases 2; Cdk4, cyclin-dependent kinases 4; PCNA, proliferating cell nuclear antigen; PI3K/Akt/mTOR, phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin; PPAR, peroxisome proliferator-activated receptor; ROS, reactive oxygen species; TBARS, thiobarbituric acid reactive substances; VEGF, vascular endothelial growth factor.
