Table 1.
Antifungal sensitivity phenotype of Candida pararugosa strain from the patient compared with pattern described in epidemiological surveys of literature.
| Antifungal drug | Value mg/La | Value mg/Lb | Value µg/mlc | |||
|---|---|---|---|---|---|---|
| MIC | MIC50 | MIC90 | Range | GM | MIC90 | |
| ITC | 1.0 | 0.5 | 0.5 | 0.03–0.25 | 0.07 | 0.12 |
| POS | 0.12 | 0.25 | 0.5 | 0.03–0.12 | 0.08 | 0.12 |
| ISA | — | 0.5 | 1.0 | — | — | — |
| FLC | 2.0 | 16.0 | 32.0 | 0.25–2 | 0.76 | 2 |
| VRC | 0.12 | 0.5 | 1.0 | <0.03–0.12 | 0.03 | 0.06 |
| ANI | 0.06 | 1.0 | >4.0 | 0.03–0.12 | 0.06 | 0.12 |
| MICA | 0.12 | 0.25 | >4.0 | 0.06–0.12 | 0.1 | 0.12 |
| CAS | 0.25 | 1.0 | >4.0 | 0.03–0.25 | 0.13 | 0.25 |
| AMB | 1.0 | 0.5 | 1.0 | 0.25–1 | 0.47 | 1 |
ITC, itraconazole; POS, posaconazole; ISA, isavuconazole; FLC, fluconazole; VRC, voriconazole; ANI, anidulafungin; MICA, micafungin; CAS, caspofungin; AMB, amphotericin B. a, values obtained on C. pararugosa strain of this report; b, values obtained on isolates of reference [7]; c, values obtained on isolates of reference [6]. MIC50, the minimal concentration of drug capable of inhibiting the growth of 50% of assayed isolates. MIC90, the minimal concentration of drug capable of inhibiting the growth of 90% of assayed isolates. GM, geometric mean. —, value not calculated.