Fig. 5.

Low doses of RT have no effect on PR8 virus expansion. (A) Mice were treated with PR8 influenza virus (H1N1) or PBS by intranasal instillation. After 2 days, mice were irradiated at the whole thorax at 0.5 Gy or 1 Gy or treated with dex. (B) Virus titers were measured in the BAL 4 days after animal infection. Data were obtained from 2 independent experiments (n = 6). Symbols indicate means and error bars indicate ±SEMs. ***P < .001 (1-way ANOVA). Abbreviations: ANOVA = analysis of variance; BAL = bronchoalveolar lavage; BALF = broncho-alveolar lavage fluid; dex = dexamethasone; Gy = Gray; PBS = phosphate-buffered saline; PFU = plaque-forming unit; RT = radiation therapy; SEM = standard error of the mean.