Table 2.

Univariate and multivariate analyses of prognostic factors with TTR and OS in glioma (n = 164).

Variables	TTR		OS
	HR (95% CI)	P	HR (95% CI)	P
Univariate analysisa
Age (≤50 vs. å 50)	2.189 (1.428–3.355)	<0.001	2.542 (1.510–4.277)	<0.001
Gender (male vs. female)	0.731 (0.466–1.145)	0.171	0.703 (0.398–1.239)	0.223
Location		0.063		0.019
(Frontal vs. temporal)	1.720 (1.007–2.938)	0.047	1.661 (0.841–3.281)	0.144
(Frontal vs. parietal)	1.175 (0.476–2.898)	0.727	1.284 (0.419–3.940)	0.662
(Frontal vs. occipital)	2.190 (0.934–5.137)	0.072	3.775 (0.760–1.377)	0.005
(Frontal vs. others)	0.876 (0.470–1.634)	0.678	0.283 (1.501–9.494)	0.643
WHO grade (I + II vs. III + IV)	6.348 (3.997–10.082)	<0.001	13.968 (0.760–1.377)	<0.001
Combination of ANXA2 and GPC1b		<0.001		<0.001
(I vs. IV)	7.356 (4.043–13.385)	<0.001	5.396 (2.763–10.539)	<0.001
(II vs. IV)	3.162 (1.849–5.404)	<0.001	4.178 (2.140–8.159)	<0.001
(III vs. IV)	7.268 (2.921–18.081)	<0.001	4.987 (1.842–13.501)	0.002
(I vs. III)	1.012 (0.412–2.486)	0.979	1.082 (0.399–2.933)	0.877
(I vs. II)	2.327 (1.376–3.935)	0.002	1.291 (0.659–2.930)	0.456
(III vs. II)	2.299 (0.968–5.461)	0.059	1.194 (0.440–3.235)	0.728
Multivariate analysisa
Age (≤50 vs. å 50)	1.716 (1.985–2.716)	0.021	1.891 (1.067–3.353)	0.029
Gender (male vs. female)	NA	NA	NA	NA
Location		0.447		0.058
(Frontal vs. temporal)	1.515 (0.875–2.621)	0.138	1.618 (0.803–3.261)	0.178
(Frontal vs. parietal)	0.946 (0.375–2.386)	0.907	1.469 (0.466–4.631)	0.512
(Frontal vs. occipital)	1.892 (0.781–4.581)	0.158	4.394 (1.658–11.649)	0.003
(Frontal vs. others)	1.361 (0.698–2.653)	0.365	1.461 (0.604–3.529)	0.400
WHO grade (I + II vs. III + IV)	5.703 (3.475–9.358)	<0.001	14.294 (6.523–31.323)	<0.001
Combination of ANXA2 and GPC1b		<0.001		0.001
(I vs. IV)	3.575 (1.880–6.799)	<0.001	2.174 (0.760–1.377)	0.045
(II vs. IV)	2.341 (1.340–4.092)	0.003	3.459 (1.685–7.104)	0.001
(III vs. IV)	7.352 (2.833–19.081)	<0.001	5.754 (1.987–16.663)	0.001
(I vs. III)	0.486 (0.190–1.244)	0.133	0.379 (0.132–1.082)	0.070
(I vs. II)	1.527 (0.883–2.640)	0.130	0.629 (0.309–1.281)	0.201
(III vs. II)	3.140 (1.266–7.787)	0.014	1.663 (0.587–4.717)	0.339

TTR time to recurrence, OS overall survival, HR hazard ratio, CI confidential interval, NA not adopted.

P values less than 0.05 were considered statistically significant.

^aCox proportional hazards regression.

^bI, ANXA2^low/GPC1^low; II, ANXA2^low/GPC1^high; III, ANXA2^high/GPC1^low; IV, ANXA2^high/GPC1^high.