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. 2021 Mar 12;11:5817. doi: 10.1038/s41598-021-85089-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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DUSP3 deletion exacerbate insulin resistance under HFD. Fasting blood insulin (a), blood glucose (b) and HOMA-IR (c) in DUSP3-KO and WT mice under CD or HFD. At all-time points, mice were starved for 6 h and blood was collected from tail vein to measure insulin and glucose. T0, basal level, corresponds to the measurement at the starting day of HFD. T1, T2 and T3 correspond respectively to 4 weeks, 12 weeks and 20 weeks under HFD or CD. N = 5 mice in each group of T1 to T3. N = 10 mice in each group at T0. (d) Fasting blood insulin in 24 weeks (left panel) and 32 weeks (right panel) after DEN challenge of DUSP3-KO and WT mice under CD or HFD. N = 5 mice in each group. Data represent means ± SD. Significance was determined by one-way ANOVA.