Table 1.

Benchmarking reconstructed core GRNs against experimentally validated core networks.

Cell type	GS interactions	Inferred interactions	Matching interactions	Mismatching interactions	Newly inferred	Newly inferred (validated)	Overall validated
ESC	9	9	9	0	0	0	100%
Hepatocytes	13	12	8	2	4	4	85.71%
HepG2	16	16	16	0	0	0	100%
MCF7	13	4	4	0	0	0	100%

For four well-characterized human cell types and cell lines, the reconstructed core networks were compared against their experimentally validated gold-standard (GS) core networks. The column ‘newly inferred’ refers to the number of interactions not present in the gold-standard network whereas the column ‘Newly inferred (validated)’ refers to how many of them were validated in literature.