Figure 3.
Associations between circulating growth differentiation factor‐15 (GDF‐15) and indices of monocyte dysfunction. (A) GDF‐15 has a strong negative correlation with maximal mitochondrial respiratory capacity (R = −0.747, P < 0.001). Maximal respiratory capacity is in pmol O2·min−1·(105 monocytes) −1 as measured by a Seahorse XFp analyzer. (B) GDF‐15 has a moderate negative correlation with IL6 fold expression following lipopolysaccharide stimulation (by 2−ΔΔCt method against B2M, R = −0.561, P = 0.046). (C) GDF‐15 has moderate positive correlation with CD16+ monocyte proportions (R = 0.571, P = 0.021). n = 6‐9/group depending on assay