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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: J Pain. 2020 Oct 6;22(3):275–299. doi: 10.1016/j.jpain.2020.09.001

Figure 6: Intraplantar injection of carrageenan (CG) induced expression changes of genes encoding for proteins involved in oxylipin release, synthesis, delivery signaling and inactivation.

Figure 6:

(A) CG was injected into the plantar surface of rat hind paw and tissue was collected at 0, 1 4, 8, 24, 48, 27 hours post injection for whole genome RNA sequencing. All genes that were statistically significantly impacted by CG injection are presented and grouped based on their function. (B) Phospholipases, (C) genes involved in oxylipin biosynthesis, (D) genes involved in delivery of preformed oxylipins to pain circuit tissues, (E) genes involved in oxylipin signaling and (F) genes involved in oxylipin esterification were all modified by CG. Gene expression is presented as mean sFPKM (n=3)