Table 1.

Heteroplasmy Shifts of mtDNA Mutations Following Cellular Reprogramming to Human iPSCs

Mutation	Initial heteroplasmy in fibroblasts	Heteroplasmy in iPSCs after reprogramming	Citation
m.3243A>G	77.70%	3.6 – 99.4%b	[53]
	69.67%	1.11% – 85.05%b	[55]
	66.30%	0.67% – 2.00%b	[55]
	29%	33 – 100%b	[54]
	50%	47.5 – 97.5%a	[22]
	80%	62.5% – 92.5%a	[22]
	80%	67.5% – 97.5%b	[22]
	50%	47.5% – 92.5%a	[22]
	80%	72.5% – 97.5%a	[22]
	80%	67.5% – 97.5%b	[22]
m.13513G>A	84%	0 – 100%b	[54]
	50%	0 – 56%b	[48]
m.8993T>C	52%	0 – 87%a	[54]
	85%	88%	[104]
	55%	32%	[105]
m.11778G>C	100%	100%*	[106]
	100%	100%*	[106]
m.14484T>C +	100%	100%*	[106]
m.4160T>C
m.8344A>G	90%	70%	[56]
	60%	60%	[56]

^*From a homoplasmic cell line

^aeven distribution

^bskewed distribution