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. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: Eur J Med Chem. 2021 Jan 31;214:113232. doi: 10.1016/j.ejmech.2021.113232

Scheme 6.

Scheme 6.

Introducing an isobutyl group at C3. Reagents and conditions: (a) isovaleryl chloride, pyridine, CHCl3, rt, 2 h, 80%; (b) AlCl3, CH2Cl2, rt, 2 h, 51%; (c) 2-hydrazinopyridine, EtOH, 80 °C, 2 h, 95%; (d) NBS, CHCl3, 60 °C, 40 min, 58%.