Skip to main content
. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: Eur J Med Chem. 2021 Jan 31;214:113232. doi: 10.1016/j.ejmech.2021.113232

Scheme 2.

Scheme 2.

Synthesis of analogues 18a-18d. Reagents and conditions: (a) acetyl chloride, pyridine, CHCl3, rt; (b) AlCl3, CH2Cl2, rt; (c) 2-hydrazinopyridine, EtOH, 80 °C; (d) NBS, CHCl3, 60 °C.