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. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: Eur J Med Chem. 2021 Jan 31;214:113232. doi: 10.1016/j.ejmech.2021.113232

Scheme 4.

Scheme 4.

Synthesis of analogues 22 and 23. Reagents and conditions: (a) CeCl3, NaBH4, MeOH/THF, −40 to −10 °C, 30 min, 20%; (b) H2NOH·HCl, NaOAc, 1,4-dioxane, reflux, 6 h, 48%.