Skip to main content
. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: Eur J Med Chem. 2021 Jan 31;214:113232. doi: 10.1016/j.ejmech.2021.113232

Table 1.

CDK2/cyclin A inhibitory activities of analogues with modified R groups on C3, C4, C5, C6, C7 and N1

graphic file with name nihms-1668598-t0003.jpg
Compound R1 R2 R3 R4 R5 R6 IC50 (μM)
3 Me =O H Me, Me Br H 2.6 ± 0.1
2 Me =O H Me, Me H H 110 ± 5
4 Me =O H Me, Me F H 21 ± 0.5
5 Me =O H Me, Me OMe H 46 ± 2
6 Me =O H Me, Me OH H 110 ± 12
7 Me =O H Me, Me Cl H 4.9 ± 0.3
8 Me =O H Me, Me Me H 200 ± 16
9 Me =O H Me, Me NMe2 H 630 ± 11
10 Me =O H Me, Me SPh H 12 ± 1
11 Me =O H Me, Me SO2Ph H 107 ± 5
12 Me =O H Me, Me N3 H 4.5 ± 0.2
13 Me =O H Me, Me NH2 H 350 ± 36
18a Me =O H H, H Br H 130 ± 6
18b-trans Me =O H Me, H Br H 4.8 ± 0.1
18b-cis Me =O H Me, H Br H 31.0 ± 0.9
18c-trans Me =O H isopropyl, H Br H 130 ± 7
18c-cis Me =O H isopropyl, H Br H 470 ± 80
18d Me =O H Ph, H Br H > 1000
22 Me OH H Me, Me Br H 560 ± 63
23 Me =NOH H Me, Me Br H 59 ± 3
24 H =O H Me, Me H H > 1000
25 H =O H Me, Me Br H 160 ± 10
27 isobutyl =O H Me, Me Br H 820 ± 660
39 Me =O H Me, Me Br Me > 1000
40 Me =O Br Me, Me H Me 180 ± 20
46 Me =O H Me, Me Br CF3 460 ± 50
47 Me =O Br Me, Me H CF3 230 ± 20
Staurosporine ~50