Multidrug-resistant (MDR) Gram-negative (GN) infections have become a major health problem worldwide.

Intravascular infections are particularly challenging when they involve non-removable devices and are caused by MDR microorganisms.

Cefiderocol is a promising added drug to the available armamentaria against MDR Gram-negative bacteria.

The cases reported here suggest the potential use of cefiderocol in foreign-body infections.

Cefiderocol could induce drug-related thrombocytopenia.