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. 2021 Feb 22;2(2):zqab010. doi: 10.1093/function/zqab010

Figure 1.

Figure 1.

Functional Hyperemia is Impaired in 5xFAD Mice In vivo. Representative 3D in vivo images showing the vascular network (red) and β-amyloid plaques (yellow) accumulated in the cortex of (a) control and (b) 5xFAD mice. Block width = 425 × 425 μm; block depth = 300 μm (n = 3 mice each). (c) Representative traces (left) and summary data (right) showing WS-induced changes in CBF in control and 5xFAD mice (n = 5 mice each; **P < 0.01, ***P < 0.001, two-way ANOVA with Tukey’s test as post hoc analysis). (d) Representative line scans (1 s each) and summary data showing RBC flux responses to 10 mM K+ in control (baseline, 35 ± 4 cells/s; 10 mM K+, 60 ± 5 cells/s; n = 10 paired experiments, five mice) and 5xFAD mice (baseline, 27 ± 4 cells/s; 10 mM K+, 32 ± 4 cells/s; n = 10 paired experiments, five mice). **P < 0.01 (paired Student’s t-test).