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. 2021 Mar 12;4:332. doi: 10.1038/s42003-021-01857-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Lubricin (brown) is expressed in superficial zone chondrocytes (SZCs; adjacent to red bar) and not in deep zone chondrocytes (DZCs; adjacent to green bar) in bovine articular cartilage. Image of lubricin immunostaining taken from⁴⁴. b Relative expression of genes that are differentially expressed in superficial zone bovine articular chondrocytes (SZC) versus deep zone bovine articular chondrocytes (DZC). Maximal and minimal expression levels in SZCs and DZCs are indicated by the intensity of the red and green hues, respectively. c Volcano plot of differentially expressed genes (DEGs) in SZCs and DZCs. Each dot represents one gene. The red dots represent SZC-specific DEGs, the green dots represent DZC-specific DEGs. Note that the TF gene Creb5 was as differentially expressed as Prg4, with ~25-fold higher levels in SZCs than in DZCs.