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. 2021 Mar 12;12:1654. doi: 10.1038/s41467-021-21921-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — a Elevated ADAR1 and RNase H2A expression levels detected in non-ALT cells. Western blotting analysis was performed using total cell extract proteins and specific antibodies (Supplementary Data 4). b Interaction between ADAR1p110 and RNase H2 detected only in non-ALT cancer cells. FLAG-ADAR1p110-WT recombinant protein was copurified with endogenous RNase H2 subunit H2A only from non-ALT cell lines. c Elevated RNase H2A expression levels and also increased interaction of ADAR1p110 with RNase H2A detected specifically at M phase. FLAG-ADAR1p110-WT pull-down experiments were conducted using HEK293T cells synchronized at M phase using the thymidine-nocodazole double block system. a–c Protein molecular weight markers are presented in Source Data file.