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. 2021 Mar 12;12:1654. doi: 10.1038/s41467-021-21921-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a–c In vitro editing assay for telomeric repeat dsRNA (a) and RNA:DNA hybrids (b, c) containing A–C or C–A mismatches was conducted using ADAR1p110-WT recombinant protein. PCR products (RT-PCR-amplified RNA strands and PCR-amplified DNA strands) were subjected to Sanger sequencing. Editing frequency estimated for three independent experiments (n = 3, technical replicates) is presented in Supplemental information (Supplementary Data 2 and Source Data file).