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. 2021 Mar 12;12(3):264. doi: 10.1038/s41419-021-03538-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a ChIP-seq binding profiles for H3K27ac enrichment were used to identify the super-enhancer in a variety of cancer cells. b The constituent enhancers of the super-enhancer (E1-E3) were identified based on markers of H3K27ac, P300, and DNase I in HeLa, HCT-116 and MCF-7 cells. c ChIP-qPCR analysis of H3K27ac in E1-E3 component enhancers in HeLa, HCT-116 and MCF-7 cells. d Promoters interacting with the super-enhancer were analyzed by GeneHancer database.