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. 2021 Mar 12;11:5838. doi: 10.1038/s41598-021-84708-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Recurrent EZH2 mutations. (a) Schematic overview of EZH2 protein structure (NM_004456.4) and identified mutations (27 in total, c.2195+1G>A appeared twice) in a cohort of 664 AML patients at diagnosis. Functional domains are indicated at distinct locations and truncating mutations are displayed in red. Patients from Metzeler et al. 2016 (AMLCG-1999, AMLCG-2008). (b–c) Survival analysis of patients with low or high EZH2 mRNA expression at the time point of diagnosis. EZH2 high and low groups defined by the upper and lower quartile of EZH2 mRNA expression, independent of mutation status. (b) Relapse-free survival (RFS). (c) Overall survival (OS). Patients from AMLCG 1999 (GSE37642), n = 517. 21 patients harboured an EZH2 mutation. P-value calculated by log-rank test.