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. 2021 Mar 12;11:5845. doi: 10.1038/s41598-021-85186-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Relationships of fluorine-18 fluorodeoxyglucose (¹⁸F-FDG) uptake on positron emission tomography/computed tomography (PET/CT) with programmed death-ligand 1 (PD-L1) expression and cluster of differentiation 8 (CD8) + and forkhead box protein P3 (Foxp3) + tumor-infiltrating lymphocyte (TIL) counts. The rate of PD-L1 positivity in patients with a high maximum standardized uptake value (SUVmax) of ¹⁸F-FDG was significantly higher than those with low SUVmax (A). CD8 + TIL counts in patients with high SUVmax of ¹⁸F-FDG were lower than those with low SUVmax (B). Foxp3 + TIL counts in patients with high SUVmax of ¹⁸F-FDG were higher than those with low SUVmax (C).