Table 2. Comparison of neuronal changes observed in human DS and the Ts65DN mouse model.

	DS (Human)	Ts65DN
Brain volume	↓	↓
Neuronal density	↓	↓
Cerebellar volume	↓	↓
Neurogenesis	Slow cell cycle	Slow cell cycle
	Impaired proliferation of neural precursors	Impaired proliferation of neural precursors
	Impaired differentiation	Impaired differentiation
Dendrite morphology	Reduced density	Reduced density
	Abnormal morphology	Abnormal morphology
Electrophysiology	EEG abnormalities EEE coherence abnormalities	EEG abnormalities EEG coherence abnormalities impaired long-term potentiation

Adapted from [83].