Table 3. Summary of the behavioural similarities between human DS and mouse models of DS.
| DS (Human) | Ts65Dn | Dep(17)1Yey/+ | Dep(10)1Yey/+ | Ts1Yah | |
|---|---|---|---|---|---|
| Spatial context discrimination | ↓ | ↓ | = | = | |
| Spatial learning and memory | ↓ | ↓ | = | = | ↑ |
| Working memory | ↓ | ↓ |
Ts65Dn animals share many similar deficits (down arrow) in learning and memory with human DS compared with control, while some other mouse models are either unaffected (=) or enhanced (up arrow) compared with control. Adapted from [78].