Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 12;12:1631. doi: 10.1038/s41467-021-21307-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — A Domain architecture of AfNADase, NcNADase and Mtb CpnT TNT. B Structure-based alignment of active site motifs of NADases and ADP-ribosyltransferases. The residues are found in three distinct regions and are coloured according to their location in the sequence. C Comparison of the active sites of AfNADase in complex with BAD, Mtb CpnT TNT, Tse6 and cholera toxin. Amino acids are coloured based on their position in the active site motif, as in (B). D Phylogenetic distribution of NADase within the kingdom fungi. Classes with the NADase are coloured red or green, red for classes without the calcium binding site and green for those with the calcium binding site, and the number in parentheses represents the number of species within the class that harbour the NADase. The calcium binding site emerged (blue star) in the Eurotiomycetes, and is only present in the order Eurotiales (inset).