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. 2021 Mar 12;12:1658. doi: 10.1038/s41467-021-21821-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — The circadian repressor REV-ERB regulates HBV and HDV entry into hepatocytes through modulating viral receptor NTCP expression. BMAL1 binds the HBV genome and promotes transcription and particle genesis. Activating REV-ERB with synthetic agonists or protein overexpression inhibits BMAL1 and represses HBV replication.