Fig. 6. HLA variants associated with the T1D risk identified through trans-ethnic fine-mapping.
Forest plots for individual risk-associated alleles are displayed along with a location map of classical HLA genes. Each forest plot shows the estimated odds ratio (OR) and 95% confidence interval from cohort-specific logistic model for BBJ and UKB, and the transethnic logistic model. Red dashed lines indicate OR in transethnic cohorts. Black solid lines represent OR = 1. Colored square boxes represent amino acid polymorphisms of the same position or a classical allele. Source data are provided as a Source Data file. BBJ BioBank Japan, UKB UK Biobank.