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. Author manuscript; available in PMC: 2021 Mar 13.
Published in final edited form as: Mol Nutr Food Res. 2015 Feb 23;59(4):763–772. doi: 10.1002/mnfr.201400705

Figure 2. Apigenin reduces the expression of LPS-induced primary miR-155 transcript.

Figure 2

A. Macrophages were treated with 100 ng/ml LPS in the presence of 50 µM apigenin (Api+LPS) or diluent DMSO (LPS), apigenin with PBS (Api) or both vehicles PBS and DMSO (DMSO) for 8 h. Pri-miR-155 expression was analyzed by qRT-PCR. B. qRT-PCR of pre-miR in the same samples described in (A). For B and C, miR expression is represented as fold change relative to DMSO control. Mean ± SEM, n=4, *p < 0.05. C. Schematic representation of miR processing. Primary transcript, pri-miR-155, is transcribed and cleaved into a precursor or pre-miR-155 and subsequently exported to the cytoplasm and further processed into mature miR-155 by a Dicer-containing complex.