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. 2021 Jan 30;10(4):e017835. doi: 10.1161/JAHA.120.017835

Figure 2. Oxidative phosphorylation genes are downregulated in pressure overload‐induced right ventricle (RV) failure but upregulated in the left ventricle (LV) of RV failure.

Figure 2

A, Oxidative phosphorylation genes dysregulated in RV failure (vs Sham RV) were compared with genes dysregulated in the LV (vs Sham LV) of RV failure hearts (n=4/group). Complex I, II, III, and V genes and cytochrome oxidase genes are downregulated in RV failure. ☒ indicates omitted values due to the cutoff set at ±0.6 log2 fold difference. The scale unit is log2 fold change. RV failure vs Sham RV q value=2.0E‐6 and LV of RV failure vs Sham LV q value=1.46E‐8. Graphical representations of the site of dysregulated oxidative phosphorylation genes in (B) RV failure and (C) LV of RV failure hearts. Blue—downregulated, Red—upregulated. The figures for (B and C) were obtained with iPathwayGuide (www.advaitabio.com) using OXPHOS pathway data from the kyoto encyclopedia of genes and genomes resource, pathway #00190. 33 , 34 , 35 LV indicates left ventricle; and RV, right ventricle.