Table 2.
Pathways | Gene Ontology | |||
---|---|---|---|---|
Name | Changes | Biological Processes | Molecular Functions | Cellular Components |
Ribosome | ↑ | Translation | Structural constituent of ribosome | Cytosolic ribosome |
Oxidative phosphorylation | ↑ | Peptide metabolic process | Structural molecule activity | Extracellular space |
Non‐alcoholic fatty liver disease | ↑ | Peptide biosynthetic process | rRNA binding | Ribosome |
Parkinson disease | ↑ | Amide biosynthetic process | Translation factor activity, RNA binding | Cytosolic part |
Huntington disease | ↑ | Cellular amide metabolic process | Neurotransmitter receptor activity | Extracellular region part |
Alzheimer disease | ↑ | Multicellular organismal process | Extracellular matrix structural constituent | Cytosolic small ribosomal subunit |
Forkhead box signaling pathway | ↑ | Regulation of multicellular organismal process | Protein‐containing complex binding | Ribosomal subunit |
HIF‐1 signaling pathway | Mixed | ATP metabolic process | Translation initiation factor activity | Collagen‐containing extracellular matrix |
Insulin resistance | ↓ | Ribosomal small subunit assembly | Proton transmembrane transporter activity | Extracellular region |
Thermogenesis | ↑ | Purine nucleoside monophosphate metabolic process | Extracellular matrix binding | Extracellular matrix |
RNA sequencing of left ventricular myocardium from RV pressure overload‐induced RV failure identified the following significantly dysregulated pathways (q≤0.004); Gene Ontology‐Biological Processes (q≤0.0007); Gene Ontology‐Molecular Functions (q≤0.01); Gene Ontology‐Cellular Components (q≤6.35E‐09). The maximum q value of the 10 pathways and gene ontology terms has been shown. ↑ indicates upregulated; ↓, downregulated. HIF‐1, hypoxia inducible factor‐1; and RV, right ventricle.