Table 2.

Top 10 Dysregulated Pathways and Gene Ontology Terms in the Left Ventricle in Right Ventricle Failure

Pathways		Gene Ontology
Name	Changes	Biological Processes	Molecular Functions	Cellular Components
Ribosome	↑	Translation	Structural constituent of ribosome	Cytosolic ribosome
Oxidative phosphorylation	↑	Peptide metabolic process	Structural molecule activity	Extracellular space
Non‐alcoholic fatty liver disease	↑	Peptide biosynthetic process	rRNA binding	Ribosome
Parkinson disease	↑	Amide biosynthetic process	Translation factor activity, RNA binding	Cytosolic part
Huntington disease	↑	Cellular amide metabolic process	Neurotransmitter receptor activity	Extracellular region part
Alzheimer disease	↑	Multicellular organismal process	Extracellular matrix structural constituent	Cytosolic small ribosomal subunit
Forkhead box signaling pathway	↑	Regulation of multicellular organismal process	Protein‐containing complex binding	Ribosomal subunit
HIF‐1 signaling pathway	Mixed	ATP metabolic process	Translation initiation factor activity	Collagen‐containing extracellular matrix
Insulin resistance	↓	Ribosomal small subunit assembly	Proton transmembrane transporter activity	Extracellular region
Thermogenesis	↑	Purine nucleoside monophosphate metabolic process	Extracellular matrix binding	Extracellular matrix

RNA sequencing of left ventricular myocardium from RV pressure overload‐induced RV failure identified the following significantly dysregulated pathways (q≤0.004); Gene Ontology‐Biological Processes (q≤0.0007); Gene Ontology‐Molecular Functions (q≤0.01); Gene Ontology‐Cellular Components (q≤6.35E‐09). The maximum q value of the 10 pathways and gene ontology terms has been shown. ↑ indicates upregulated; ↓, downregulated. HIF‐1, hypoxia inducible factor‐1; and RV, right ventricle.