Table 2.
Association With Outcomes Stratified by Fluid Removal in the First 24 Hours (Above and Below Median) and Ejection Fraction (≤40% Versus >40%)
| Volume Removed in First 24 h | Baseline Ejection Fraction | |||||
|---|---|---|---|---|---|---|
| Low Volume Removal (n=46) | High Volume Removal (n=47) | P Value* | EF ≤40% (n=59) | EF >40% (n=35) | P Value* | |
| Net urine output at 96 h, L | 6.23 (3.87, 9.87) | 9.08 (5.91,10.52) | 0.027 | 6.98 (4.09, 10.3) | 7.28 (4.63,10.6) | 0.420 |
| ∆ Weight, lbs | ↓9.67 (−13.60, −5.73) | ↓13.89 (−22.71, −7.28) | 0.044 | ↓11.55 (−15.40, −5.95) | ↓11.68 (−18.30, −7.05) | 0.690 |
| ∆ Creatinine, mg/dL | ↑0.10 (−0.12, 0.53) | ↑0.10 (−0.31, 0.57) | 0.601 | ↓0.04 (−0.31, 0.42) | ↑0.19 (−0.01, 0.96) | 0.023 |
| ∆ Serum urea nitrogen | ↑9.50 (−2.00, 22.00) | ↑12.00 (−3.00, 24.00) | 0.756 | ↑4.00 (−3.00, 19.00) | ↑17.50 (1.00–32.00) | 0.029 |
| ∆N‐terminal pro–brain natriuretic peptide, pg/mL | ↓273.70 (−2149.00, 1172.00) | ↓656.00 (−1516.00, 54.30) | 0.331 | ↓836.00 (−2748.00, 30.30) | ↓108.40 (−1046.00, 266.00) | 0.068 |
| ∆ Plasma renin activity, ng/mL/hr | ↑1.68 (−0.53, 10.37) | ↑8.66 (−0.09, 19.8) | 0.134 | ↑2.21 (−0.18, 13.49) | ↑6.06 (0.16, 14.01) | 0.537 |
| ∆ Aldosterone, ng/dL | ↓0.55 (−98.07, 47.5) | ↓23.54 (−90.84, 161.91) | 0.780 | ↓31.76 (−199.90, 50.75) | ↑2.87 (−35.58, 108.27) | 0.038 |
| Congestion at 96 h | 39/43 (90.7%) | 35/39 (89.7%) | 1.000 | 45/50 (90%) | 29/32 (90.6%) | 1.000 |
| Length of stay, d † | 8 (6, 13) | 6 (4, 9) | 0.010 | 7 (5, 11) | 7 (5, 13) | 0.624 |
| Death, hospital, or emergency department/urgent care | 28/46 (60.9%) | 34/46 (73.9%) | 0.182 | 40/59 (67.8%) | 22/34 (64.7%) | 0.761 |
∆–change from baseline to 96 hours. EF indicates ejection fraction.
*
P value represents Median for patients with ultrafiltration is equal 1.89L. Wilcoxon rank‐sum test or Pearson chi‐square test or Fisher's exact test.
†
days from randomization to discharge.